Prevention and control of multi-drug-resistant Gram-negative bacteria: recommendations from a Joint Working Party

Wilson, A. P. R., Livermore, D. M. ORCID:, Otter, J. A., Warren, R. E., Jenks, P., Enoch, D. A., Newsholme, W., Oppenheim, B., Leanord, A., McNulty, C., Tanner, G., Bennett, S., Cann, M., Bostock, J., Collins, E., Peckitt, S., Ritchie, L., Fry, C. and Hawkey, P. (2016) Prevention and control of multi-drug-resistant Gram-negative bacteria: recommendations from a Joint Working Party. Journal of Hospital Infection, 92 (Supplement 1). S1–S44. ISSN 0195-6701

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Multi-drug-resistant (MDR) Gram-negative bacterial infections have become prevalent in some European countries. Moreover, increased use of broad-spectrum antimicrobial agents selects organisms with resistance and, by increasing their numbers, increases their chance of spread. This report describes measures that are clinically effective for preventing transmission when used by healthcare workers in acute and primary healthcare premises. Methods for systematic review 1946–2014 were in accordance with SIGN 501 and the Cochrane Collaboration;2 critical appraisal was applied using AGREEII.3 Accepted guidelines were used as part of the evidence base and to support expert consensus. Questions for review were derived from the Working Party Group, which included patient representatives in accordance with the Patient Intervention Comparison Outcome (PICO) process. Recommendations are made in the following areas: screening, diagnosis and infection control precautions including hand hygiene, single-room accommodation, and environmental screening and cleaning. Recommendations for specific organisms are given where there are species differences. Antibiotic stewardship is covered in a separate publication.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 22 Dec 2015 14:04
Last Modified: 21 Oct 2022 01:11
DOI: 10.1016/j.jhin.2015.08.007

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