Rethinking paradigms for studying mechanisms of action of plant bioactives

Kay, C.D. (2015) Rethinking paradigms for studying mechanisms of action of plant bioactives. Nutrition Bulletin, 40 (4). pp. 335-339. ISSN 1467-3010

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Many foods in our diets such as berries, tea, chocolate and wine contain flavonoids, which are natural components of plants. A substantial body of evidence supports the role of flavonoids in providing protection against cardio-metabolic diseases and disorders. Despite the nearly exponential growth in flavonoid research in the past 20 years, limited progress has been made in understanding how these dietary components work. Research initially focused on their antioxidant activity without taking into account their metabolism, which now appears extensive. This has provided a new research impetus to understand the biological activity of the flavonoid metabolites. Here, we outline recent research, which suggests a highly complex interplay between metabolism, intestinal microflora, the immune system and various tissues of our body.

Item Type: Article
Additional Information: © 2015 The Authors. Nutrition Bulletin published by John Wiley & Sons Ltd on behalf of British Nutrition Foundation. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: anti-inflammatory,bioactivity flavonoid,metabolism,microflora,vascular
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
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Depositing User: Pure Connector
Date Deposited: 01 Dec 2015 07:35
Last Modified: 04 May 2023 21:31
DOI: 10.1111/nbu.12178


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