Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans

Arif, Sayqa, Borgognone, Alessandra, Lin, Erica Lai-Sze, O'Sullivan, Aine, Sharma, Vishal, Drury, Nigel, Menon, Ashvini, Nightingale, Peter, Mascaro, Jorge, Bonser, Robert S, Horowitz, John, Feelisch, Martin, Frenneaux, Michael and Madhani, Melanie (2015) Role of aldehyde dehydrogenase in hypoxic vasodilator effects of nitrite in rats and humans. British Journal of Pharmacology, 172 (13). pp. 3341-3352. ISSN 0007-1188

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Abstract

Hypoxic conditions favour the reduction of nitrite to nitric oxide (NO) to elicit vasodilatation, but the mechanism(s) responsible for bioconversion remains ill defined. In the present study, we assess the role of aldehyde dehydrogenase 2 (ALDH2) in nitrite bioactivation under normoxia and hypoxia in the rat and human vasculature.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 01 Dec 2015 07:25
Last Modified: 02 Nov 2020 00:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/55525
DOI: 10.1111/bph.13122

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