Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay?

Sakel, Mohamed, Boukouvalas, Alexis, Buono, Romain, Moten, Maliha, Mirza, Farhat, Chan, Wei Yee, Maidment, Ian D, Cross, Jane, Smith, Toby, Myint, Phyo and Fox, Chris (2015) Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay? Brain Injury, 29 (12). pp. 1426-1430. ISSN 0269-9052

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Primary Objective: To assess the relationship between disability, length of stay (LOS) and anticholinergic burden (ACB) with people following acquired brain or spinal cord injury. Research Design: A retrospective case note review assessed total rehabilitation unit admission. Methods & Procedures: Assessment of 52 consecutive patients with acquired brain/spinal injury and neuropathy in an in-patient neuro-rehabilitation unit of a United Kingdom university hospital. Data analysed included: Northwick Park Dependency Score (NPDS), Rehabilitation complexity Scale (RCS), Functional Independence Measure and Functional Assessment Measure FIM-FAM (UK version 2.2), LOS and ACB. Outcome was different in RCS, NPDS and FIM-FAM between admission and discharge. Main Outcomes & Results: A positive change was reported in ACB results in a positive change in NPDS with no significant effect on FIM-FAM, either Motor or Cognitive, or on the RCS. Change in ACB correlated to the length of hospital stay (regression correlation: -6.64; SE: 3.89). There was a significant harmful impact of increase in ACB score during hospital stay, from low to high ACB on NPDS (OR=9.65; 95% CI: 1.36 to 68.64) and FIM-FAM Total scores (OR=0.03; 95% CI: 0.002 to 0.35). Conclusions: There was a statistically significant correlation of ACB and neuro-disability measures and LOS amongst this patient cohort.

Item Type: Article
Uncontrolled Keywords: anticholinergic ,burden,brain injury,spinal cord injury,medications,adverse effects,rehabilitation
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Medicine and Health Sciences > School of Health Sciences
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Depositing User: Pure Connector
Date Deposited: 01 Dec 2015 07:23
Last Modified: 22 Jul 2020 00:17
DOI: 10.3109/02699052.2015.1060358

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