Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay?

Sakel, Mohamed, Boukouvalas, Alexis, Buono, Romain, Moten, Maliha, Mirza, Farhat, Chan, Wei Yee, Maidment, Ian D, Cross, Jane ORCID: https://orcid.org/0000-0002-7003-1916, Smith, Toby ORCID: https://orcid.org/0000-0003-1673-2954, Myint, Phyo and Fox, Chris ORCID: https://orcid.org/0000-0001-9480-5704 (2015) Does anticholinergics drug burden relate to global neuro-disability outcome measures and length of hospital stay? Brain Injury, 29 (12). pp. 1426-1430. ISSN 0269-9052

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Abstract

Primary Objective: To assess the relationship between disability, length of stay (LOS) and anticholinergic burden (ACB) with people following acquired brain or spinal cord injury. Research Design: A retrospective case note review assessed total rehabilitation unit admission. Methods & Procedures: Assessment of 52 consecutive patients with acquired brain/spinal injury and neuropathy in an in-patient neuro-rehabilitation unit of a United Kingdom university hospital. Data analysed included: Northwick Park Dependency Score (NPDS), Rehabilitation complexity Scale (RCS), Functional Independence Measure and Functional Assessment Measure FIM-FAM (UK version 2.2), LOS and ACB. Outcome was different in RCS, NPDS and FIM-FAM between admission and discharge. Main Outcomes & Results: A positive change was reported in ACB results in a positive change in NPDS with no significant effect on FIM-FAM, either Motor or Cognitive, or on the RCS. Change in ACB correlated to the length of hospital stay (regression correlation: -6.64; SE: 3.89). There was a significant harmful impact of increase in ACB score during hospital stay, from low to high ACB on NPDS (OR=9.65; 95% CI: 1.36 to 68.64) and FIM-FAM Total scores (OR=0.03; 95% CI: 0.002 to 0.35). Conclusions: There was a statistically significant correlation of ACB and neuro-disability measures and LOS amongst this patient cohort.

Item Type: Article
Uncontrolled Keywords: anticholinergic ,burden,brain injury,spinal cord injury,medications,adverse effects,rehabilitation
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Medicine and Health Sciences > School of Health Sciences
Related URLs:
Depositing User: Pure Connector
Date Deposited: 01 Dec 2015 07:23
Last Modified: 30 Sep 2022 01:18
URI: https://ueaeprints.uea.ac.uk/id/eprint/55520
DOI: 10.3109/02699052.2015.1060358

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