Subregional hippocampal deformations in major depressive disorder

Cole, James, Toga, Arthur W, Hojatkashani, Cornelius, Thompson, Paul, Costafreda, Sergi G, Cleare, Anthony J, Williams, Steven C R, Bullmore, Edward T, Scott, Jan L, Mitterschiffthaler, Martina T, Walsh, Nicholas D ORCID:, Donaldson, Catherine, Mirza, Mubeena, Marquand, Andre, Nosarti, Chiara, McGuffin, Peter and Fu, Cynthia H Y (2010) Subregional hippocampal deformations in major depressive disorder. Journal of Affective Disorders, 126 (1-2). pp. 272-277. ISSN 0165-0327

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BACKGROUND: Hippocampal atrophy is a well reported feature of major depressive disorder, although the evidence has been mixed. The present study sought to examine hippocampal volume and subregional morphology in patients with major depressive disorder, who were all medication-free and in an acute depressive episode of moderate severity. METHODS: Structural magnetic resonance imaging scans were acquired in 37 patients (mean age 42 years) and 37 age, gender and IQ-matched healthy individuals. Hippocampal volume and subregional structural differences were measured by manual tracings and identification of homologous surface points to the central core of each hippocampus. RESULTS: Both right (P=0.001) and left (P=0.005) hippocampal volumes were reduced in patients relative to healthy controls (n=37 patients and n=37 controls), while only the right hippocampus (P=0.016) showed a reduced volume in a subgroup of first-episode depression patients (n=13) relative to healthy controls. Shape analysis localised the subregional deformations to the subiculum and CA1 subfield extending into the CA2-3 subfields predominantly in the tail regions in the right (P=0.017) and left (P=0.011) hippocampi. LIMITATIONS: As all patients were in an acute depressive episode, effects associated with depressive state cannot be distinguished from trait effects. CONCLUSIONS: Subregional hippocampal deficits are present early in the course of major depression. The deformations may reflect structural correlates underlying functional memory impairments and distinguish depression from other psychiatric disorders.

Item Type: Article
Additional Information: Copyright 2010 Elsevier B.V. All rights reserved.
Uncontrolled Keywords: adult,case-control studies,depressive disorder, major,female,hippocampus,humans,magnetic resonance imaging,male,organ size
Faculty \ School: Faculty of Social Sciences > School of Psychology
UEA Research Groups: Faculty of Social Sciences > Research Groups > Social and Developmental Psychology (former - to 2017)
Faculty of Social Sciences > Research Groups > Developmental Science
Faculty of Social Sciences > Research Groups > Cognition, Action and Perception
Depositing User: Pure Connector
Date Deposited: 19 Nov 2015 08:22
Last Modified: 22 Oct 2022 00:25
DOI: 10.1016/j.jad.2010.03.004

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