Virus Factories and Mini-Organelles Generated for Virus Replication

Wileman, Tom, Netherton, Chris and Powell, Penny (2016) Virus Factories and Mini-Organelles Generated for Virus Replication. In: Encyclopedia of Cell Biology. Elsevier, 819–827.

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Abstract

Many viruses replicate and assemble in subcellular microenvironments called virus factories or ‘viroplasm.’ Virus factories increase the efficiency of replication and at the same time protect viruses from antiviral defenses. We describe how viruses reorganize cellular membrane compartments and cytoskeleton to generate these ‘mini-organelles’ and how these rearrangements parallel cellular responses to stress such as protein aggregation and DNA damage.

Item Type:	Book Section
Uncontrolled Keywords:	aggresome,autophagosome,autophagy,double membrane vesicle,pml-nb,replicase,spherule,viroplasm,virus factory,virus replication
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Gastroenterology and Gut Biology Faculty of Medicine and Health Sciences > Research Centres > Metabolic Health Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User:	Pure Connector
Date Deposited:	13 Nov 2015 12:01
Last Modified:	28 Mar 2025 01:48
URI:	https://ueaeprints.uea.ac.uk/id/eprint/55187
DOI:	10.1016/B978-0-12-394447-4.20102-8

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