A longitudinal functional magnetic resonance imaging study of verbal working memory in depression after antidepressant therapy

Walsh, Nicholas D, Williams, Steven C R, Brammer, Michael J, Bullmore, Edward T, Kim, Jieun, Suckling, John, Mitterschiffthaler, Martina T, Cleare, Anthony J, Pich, Emilio Merlo, Mehta, Mitul A and Fu, Cynthia H Y (2007) A longitudinal functional magnetic resonance imaging study of verbal working memory in depression after antidepressant therapy. Biological Psychiatry, 62 (11). pp. 1236-43. ISSN 0006-3223

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Abstract

BACKGROUND: Impairments in the neural circuitry of verbal working memory are evident in depression. Factors of task demand and depressive state might have significant effects on its functional neuroanatomy. METHODS: Two groups underwent functional magnetic resonance imaging while performing a verbal working memory task of varying cognitive load (n-back). The patient group comprised 20 medication-free individuals in an acute episode of unipolar major depression and the control group comprised 20 healthy individuals. Scans were acquired at weeks 0 (baseline), 2, and 8. Patients received treatment with fluoxetine after the baseline scan. Cerebral activations were measured for mean overall activation as well as the linear and quadratic load-response activity with increasing task demand (1-, 2-, 3-back). RESULTS: There were no significant differences in performance accuracy between groups. However, a main effect of group was observed in the load-response activity in frontal and posterior cortical regions within the verbal working memory network in which patients showed a greater load-response relative to control subjects. Group by time effects were revealed in the load-response activity in the caudate and thalamus. As a marker of treatment response, a lower linear load-response at baseline in the dorsal anterior cingulate, left middle frontal, and lateral temporal cortices was associated with an improved clinical outcome. CONCLUSIONS: Maintenance of performance accuracy in patients was accompanied by a significant increase in the load-response activity in frontal and posterior cortical regions within the verbal working memory network. These data also provide further support for resilience of activity in the anterior cingulate as a predictor of treatment response in depression.

Item Type: Article
Uncontrolled Keywords: adult,antidepressive agents,antidepressive agents, second-generation,caudate nucleus,cerebral cortex,cognition,depressive disorder, major,echo-planar imaging,female,fluoxetine,humans,image processing, computer-assisted,longitudinal studies,magnetic resonance imaging,male,memory, short-term,middle aged,psychiatric status rating scales,psychomotor performance,thalamus,verbal behavior
Faculty \ School: Faculty of Social Sciences > School of Psychology
Depositing User: Pure Connector
Date Deposited: 11 Nov 2015 14:00
Last Modified: 22 Apr 2020 00:41
URI: https://ueaeprints.uea.ac.uk/id/eprint/55124
DOI: 10.1016/j.biopsych.2006.12.022

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