Increased prefrontal gyrification in a large high-risk cohort characterizes those who develop schizophrenia and reflects abnormal prefrontal development

Harris, Jonathan M, Moorhead, T William J, Miller, Patrick, McIntosh, Andrew M, Bonnici, Heidi M, Owens, David G C, Johnstone, Eve C and Lawrie, Stephen M (2007) Increased prefrontal gyrification in a large high-risk cohort characterizes those who develop schizophrenia and reflects abnormal prefrontal development. Biological Psychiatry, 62 (7). pp. 722-9. ISSN 0006-3223

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Abstract

In our cohort considered at high risk (HR) of developing schizophrenia, we previously found a significant difference in extent of right prefrontal cortical folding between those who subsequently developed schizophrenia and a matched group who remained well. This study aimed to determine if this preexisting difference distinguished 17 individuals who developed schizophrenia from the 128 HR individuals in the cohort who remained well and to explore possible underlying differences in cortical composition.

Item Type: Article
Uncontrolled Keywords: adolescent,adult,cohort studies,female,functional laterality,humans,image processing, computer-assisted,logistic models,longitudinal studies,magnetic resonance imaging,male,neuropsychological tests,prefrontal cortex,prospective studies,psychiatric status rating scales,risk,schizophrenia
Faculty \ School: Faculty of Social Sciences > School of Psychology
Depositing User: Pure Connector
Date Deposited: 10 Nov 2015 17:00
Last Modified: 31 Oct 2019 14:38
URI: https://ueaeprints.uea.ac.uk/id/eprint/55075
DOI: 10.1016/j.biopsych.2006.11.027

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