Stress--the battle for hearts and minds:links between depression, stress and ischemic heart disease

Korszun, Ania and Frenneaux, Michael P (2006) Stress--the battle for hearts and minds:links between depression, stress and ischemic heart disease. Future Cardiology, 2 (5). pp. 571-8. ISSN 1479-6678

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Abstract

Depression and ischemic heart disease (IHD) are strongly related common disorders. Depression itself is an independent cardiac risk factor and is associated with a two- to threefold increase in IHD mortality. Attention has now shifted to identifying the common underlying mechanisms that could make individuals susceptible to both disorders. Abnormalities that have been implicated in this relationship include abnormal platelet activation, decreased baroreceptor sensitivity and endothelial dysfunction. Depression and IHD both have a high association with environmental stress, and depression is characterized by abnormalities of the stress-hormone axis. This review provides a brief overview of some recent developments in our understanding of the pathophysiological links between stress, depression and IHD.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 03 Nov 2015 11:00
Last Modified: 22 Apr 2020 00:25
URI: https://ueaeprints.uea.ac.uk/id/eprint/54981
DOI: 10.2217/14796678.2.5.571

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