A systematic review of non-pharmacological interventions for primary Sjögren’s syndrome

Hackett, Katie, Deane, Katherine ORCID: https://orcid.org/0000-0002-0805-2708, Strassheim, Victoria, Deary, Vincent, Newton, Julia, Rapley, Tim and Ng, Wan-Fai (2015) A systematic review of non-pharmacological interventions for primary Sjögren’s syndrome. Rheumatology, 54 (11). pp. 2025-2032. ISSN 1462-0324

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The objective of this systematic review was to assess the efficacy of non-pharmacological interventions for the management of primary Sjögren’s syndrome. We searched the following databases from inception to September 2014; Cochrane Database of Systematic Reviews; Medline; Embase; PsychINFO; Cinahl and clinical trials registers. We included randomised controlled trials of any non-pharmacological interventions. Two review authors independently reviewed titles and abstracts against the inclusion/exclusion criteria and independently assessed trial quality and extracted data. 1463 studies were identified of which 17 full text articles were screened and 5 studies were included in the review with a total of 130 participants randomised. The included studies investigated effectiveness of an oral lubricating device for dry mouth, acupuncture for dry mouth, lacrimal punctum plugs for dry eyes and psychodynamic group therapy for coping with symptoms. Overall the studies were of low quality and at high risk of bias. Although one study showed punctum plugs to improve dry eyes it was too small for the findings to be conclusive. Overall we identified no evidence to support any non-pharmacological interventions to improve PSS. The area needs quality large randomised controlled trials that are reported according to CONSORT guidelines and address important issues to patients.

Item Type: Article
Additional Information: © The Author 2015. Published by Oxford University Press on behalf of the British Society for Rheumatology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Uncontrolled Keywords: sjogren's syndrome,systematic review,non-pharmacological interventions,rheumatology,fatigue,dryness,pain,function
Faculty \ School: Faculty of Medicine and Health Sciences > School of Health Sciences
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Community and Family Health (former - to 2017)
Faculty of Medicine and Health Sciences > Research Groups > Health in Later Life (former - to 2017)
Faculty of Medicine and Health Sciences > Research Groups > Dementia & Complexity in Later Life
Faculty of Medicine and Health Sciences > Research Centres > Lifespan Health
Depositing User: Pure Connector
Date Deposited: 23 Oct 2015 15:00
Last Modified: 19 Oct 2023 01:26
URI: https://ueaeprints.uea.ac.uk/id/eprint/54801
DOI: 10.1093/rheumatology/kev227


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