5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence

Owens, Matthew, Goodyer, Ian M., Wilkinson, Paul, Bhardwaj, Anupam, Abbott, Rosemary, Croudace, Tim, Dunn, Valerie, Jones, Peter B., Walsh, Nicholas D. ORCID: https://orcid.org/0000-0002-8195-7933, Ban, Maria and Sahakian, Barbara J. (2012) 5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence. PLoS One, 7 (11). ISSN 1932-6203

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BACKGROUND: Polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) and exposure to early childhood adversities (CA) are independently associated with individual differences in cognitive and emotional processing. Whether these two factors interact to influence cognitive and emotional processing is not known. METHODOLOGY AND PRINCIPAL FINDINGS: We used a sample of 238 adolescents from a community study characterised by the presence of the short allele of 5-HTTLPR (LL, LS, SS) and the presence or absence of exposure to CA before 6 years of age. We measured cognitive and emotional processing using a set of neuropsychological tasks selected predominantly from the CANTAB® battery. We found that adolescents homozygous for the short allele (SS) of 5-HTTLPR and exposed to CA were worse at classifying negative and neutral stimuli and made more errors in response to ambiguous negative feedback. In addition, cognitive and emotional processing deficits were associated with diagnoses of anxiety and/or depressions. CONCLUSION AND SIGNIFICANCE: Cognitive and emotional processing deficits may act as a transdiagnostic intermediate marker for anxiety and depressive disorders in genetically susceptible individuals exposed to CA.

Item Type: Article
Uncontrolled Keywords: adolescent,alleles,anxiety,cognition,depression,emotions,female,gene-environment interaction,genotype,humans,male,polymorphism, genetic,promoter regions, genetic,serotonin plasma membrane transport proteins
Faculty \ School: Faculty of Social Sciences > School of Psychology
UEA Research Groups: Faculty of Social Sciences > Research Groups > Developmental Science
Faculty of Social Sciences > Research Groups > Cognition, Action and Perception
Faculty of Social Sciences > Research Groups > Social and Developmental Psychology (former - to 2017)
Depositing User: Pure Connector
Date Deposited: 22 Oct 2015 11:00
Last Modified: 22 Oct 2022 00:21
URI: https://ueaeprints.uea.ac.uk/id/eprint/54746
DOI: 10.1371/journal.pone.0048482

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