Serial gadolinium enhanced magnetic resonance imaging in multiple sclerosis

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Miller, D. H., Rudge, P., Johnson, G., Kendall, B. E., MacManus, D. G., Moseley, I. F., Barnes, D. and McDonald, W. I. (1988) Serial gadolinium enhanced magnetic resonance imaging in multiple sclerosis. Brain, 111 (4). pp. 927-939. ISSN 0006-8950

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Abstract

Serial gadolinium-DTPA (Gd-DTPA) enhanced magnetic resonance imaging (MRI) was performed in 9 patients with multiple sclerosis (MS). On the first scan enhancing lesions were seen in 7 patients, all of whom were in acute relapse. Most enhancing lesions were asymptomatic. On the second scan (3 to 5 weeks later), persisting enhancement was seen in only 12/54 lesions which enhanced on the first scan. No lesion showed persisting enhancement on the third scan (after 6 months). Enhancement occurred in all 12 new lesion areas seen on the unenhanced second scan and in 8 of 15 new lesions seen on the third scan. Enhancement was also seen in 4 older lesions which had been nonenhancing on earlier scans. Relaxation time measurements demonstrated a high water content in some nonenhancing lesions, which could be due to a subtle blood-brain barrier disturbance not detected with Gd-DTPA. The results show that blood-brain barrier impairment is a consistent finding in new MS lesions detected with MRI. Gd-DTPA is a useful marker of new and biologically active lesions and should prove of value in monitoring therapeutic trials in MS.

Item Type:	Article
Uncontrolled Keywords:	adult,blood-brain barrier,brain pathology,gadolinium dtpa,humans,magnetic resonance imaging,middle aged,multiple sclerosis pathology,organometallic compounds adverse effects,organometallic compounds diagnostic use,pentetic acid adverse effects,pentetic acid diagnostic use,spinal cord pathology,time factors
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Related URLs:	http://brain.oxfordjournals.org/content/...
Depositing User:	Pure Connector
Date Deposited:	07 Oct 2015 14:00
Last Modified:	21 Oct 2022 01:19
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54609
DOI:

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