Serial gadolinium enhanced magnetic resonance imaging in multiple sclerosis

Miller, D. H., Rudge, P., Johnson, G., Kendall, B. E., MacManus, D. G., Moseley, I. F., Barnes, D. and McDonald, W. I. (1988) Serial gadolinium enhanced magnetic resonance imaging in multiple sclerosis. Brain, 111 (4). pp. 927-939. ISSN 0006-8950

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Serial gadolinium-DTPA (Gd-DTPA) enhanced magnetic resonance imaging (MRI) was performed in 9 patients with multiple sclerosis (MS). On the first scan enhancing lesions were seen in 7 patients, all of whom were in acute relapse. Most enhancing lesions were asymptomatic. On the second scan (3 to 5 weeks later), persisting enhancement was seen in only 12/54 lesions which enhanced on the first scan. No lesion showed persisting enhancement on the third scan (after 6 months). Enhancement occurred in all 12 new lesion areas seen on the unenhanced second scan and in 8 of 15 new lesions seen on the third scan. Enhancement was also seen in 4 older lesions which had been nonenhancing on earlier scans. Relaxation time measurements demonstrated a high water content in some nonenhancing lesions, which could be due to a subtle blood-brain barrier disturbance not detected with Gd-DTPA. The results show that blood-brain barrier impairment is a consistent finding in new MS lesions detected with MRI. Gd-DTPA is a useful marker of new and biologically active lesions and should prove of value in monitoring therapeutic trials in MS.

Item Type: Article
Uncontrolled Keywords: adult,blood-brain barrier,brain pathology,gadolinium dtpa,humans,magnetic resonance imaging,middle aged,multiple sclerosis pathology,organometallic compounds adverse effects,organometallic compounds diagnostic use,pentetic acid adverse effects,pentetic acid diagnostic use,spinal cord pathology,time factors
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
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Depositing User: Pure Connector
Date Deposited: 07 Oct 2015 14:00
Last Modified: 21 Oct 2022 01:19

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