Dynamic contrast-enhanced T2-weighted MR imaging of recurrent malignant gliomas treated with thalidomide and carboplatin

Cha, Soonmee, Knopp, Edmond A., Johnson, Glyn, Litt, Andrew, Glass, Jon, Gruber, Michael L., Lu, Stanley and Zagzag, David (2000) Dynamic contrast-enhanced T2-weighted MR imaging of recurrent malignant gliomas treated with thalidomide and carboplatin. American Journal of Neuroradiology, 21 (5). pp. 881-890. ISSN 1936-959X

Full text not available from this repository. (Request a copy)


BACKGROUND AND PURPOSE: Dynamic, contrast-enhanced MR imaging has allowed quantitative assessment of cerebral blood volume (CBV) in brain tumors. The purpose of our study was to compare postcontrast T1-weighted imaging with dynamic, contrast-enhanced T2*-weighted echo-planar imaging in the evaluation of the response of recurrent malignant gliomas to thalidomide and carboplatin. METHODS: Serial MR imaging was performed in 18 consecutive patients with recurrent malignant gliomas receiving both thalidomide and carboplatin for 12-month periods. Six patients undergoing carboplatin therapy alone were chosen as control subjects. Conventional postcontrast T1-weighted images were compared with relative CBV (rCBV) maps calculated on a pixel-by-pixel basis from dynamic echo-planar imaging data. Tumor progression was evaluated clinically using established criteria for malignant gliomas. Studies were performed at 2- to 3-month intervals, and imaging and clinical findings were compared. RESULTS: Tumor response to treatment, based on clinical findings, did not correlate well with conventional imaging findings. The rCBV values decreased significantly in all patients between the start of therapy and the first follow-up in the study group, but not in the control group. The difference in rCBV values between the clinically stable and the progressive group at 12-month follow-up was statistically significant, with the progressive group having higher values. CONCLUSION: Dynamic, contrast-enhanced MR imaging is a valuable adjunct to conventional imaging in assessing tumor activity during antiangiogenic therapy, and correlates better than conventional studies with clinical status and response to therapy.

Item Type: Article
Uncontrolled Keywords: 4z8r6ors6l (thalidomide) ,bg3f62ond5 (carboplatin),adult aged antineoplastic combined chemotherapy protocols,adverse effects,therapeutic use brain neoplasms,diagnosis,drug therapy,mortality carboplatin,administration & dosage,adverse effects echo-planar imaging female follow-up studies glioma,mortality humans ,image enhancement ,magnetic resonance imaging male middle aged neoplasm recurrence, local,mortality survival rate thalidomide
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit
Related URLs:
Depositing User: Pure Connector
Date Deposited: 18 Sep 2015 10:00
Last Modified: 21 Oct 2022 01:15
URI: https://ueaeprints.uea.ac.uk/id/eprint/54450

Actions (login required)

View Item View Item