Dynamic susceptibility contrast-enhanced perfusion and conventional MR imaging findings for adult patients with cerebral primitive neuroectodermal tumors

Law, Meng, Kazmi, Khuram, Wetzel, Stephan, Wang, Edwin, Iacob, Codrin, Zagzag, David, Golfinos, John G. and Johnson, Glyn (2004) Dynamic susceptibility contrast-enhanced perfusion and conventional MR imaging findings for adult patients with cerebral primitive neuroectodermal tumors. American Journal of Neuroradiology, 25 (6). pp. 997-1005. ISSN 1936-959X

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Abstract

BACKGROUND AND PURPOSE: Preoperative differentiation of primitive neuroectodermal tumors (PNETs) from other tumors is important for presurgical staging, intraoperative management, and postoperative treatment. Dynamic, susceptibility-weighted, contrast-enhanced MR imaging can provide in vivo assessment of the microvasculature in intracranial mass lesions. The purpose of this study was to determine the perfusion characteristics of adult cerebral PNETs and to compare those values with low and high grade gliomas. METHODS: Conventional MR images of 12 adult patients with pathologically proved cerebral PNETs were analyzed and provided a preoperative diagnosis. Relative cerebral blood volume (rCBV) measurements and estimates of the vascular permeability transfer constant, K(trans), derived by a pharmacokinetic modeling algorithm, were also obtained. These results were compared with rCBV and K(trans) values obtained in a group of low grade gliomas (n = 30) and a group of high grade gliomas (n = 55) by using a Student t test. RESULTS: On conventional MR images, PNETs were generally well-defined contrast-enhancing masses with solid and cystic components, little or no surrounding edema, and occasional regions of susceptibility. The rCBV of cerebral PNETs was 4.76 +/- 1.99 SD, and the K(trans) was 0.0033 +/- 0.0035. A comparative group of patients with low grade gliomas (n = 30) had significantly lower rCBV (P

Item Type: Article
Uncontrolled Keywords: 0 (contrast media) ,adult aged aged,80 and over brain neoplasms,pathology,physiopathology cerebrovascular circulation contrast media female humans magnetic resonance imaging,methods male middle aged neuroectodermal tumors ,primitive,physiopathology
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 23 Sep 2015 11:34
Last Modified: 22 Apr 2020 00:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/54428
DOI:

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