Correlation of diffusion tensor and dynamic perfusion MR imaging metrics in normal-appearing corpus callosum: support for primary hypoperfusion in multiple sclerosis

Saindane, A. M., Law, M., Ge, Y., Johnson, G., Babb, J. S. and Grossman, R. I. (2007) Correlation of diffusion tensor and dynamic perfusion MR imaging metrics in normal-appearing corpus callosum: support for primary hypoperfusion in multiple sclerosis. American Journal of Neuroradiology, 28 (4). pp. 767-72. ISSN 1936-959X

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Abstract

BACKGROUND AND PURPOSE: Hypoperfusion of the normal-appearing white matter in multiple sclerosis (MS) may be related to ischemia or secondary to hypometabolism from wallerian degeneration (WD). This study evaluated whether correlating perfusion and diffusion tensor imaging (DTI) metrics in normal-appearing corpus callosum could provide support for an ischemic mechanism for hypoperfusion. MATERIALS AND METHODS: Fourteen patients with relapsing-remitting MS (RRMS) and 17 control subjects underwent perfusion MR imaging and DTI. Absolute measures of cerebral blood volume (CBV), cerebral blood flow (CBF), and mean transit time (MTT) were calculated. Mean diffusivity (MD) and fractional anisotropy (FA) maps were computed from DTI data. After visual coregistration of perfusion and DTI images, regions of interest were placed in the genu, central body, and splenium of normal-appearing corpus callosum. Pearson product-moment correlation coefficients were calculated using mean DTI and perfusion measures in each region. RESULTS: In the RRMS group, CBF and CBV were significantly correlated with MD in the splenium (r = 0.83 and r = 0.63, respectively; both P <.001) and in the central body (r = 0.86 and r = 0.65, respectively; both P <.001), but not in the genu (r = 0.23 and 0.25, respectively; both P is nonsignificant). No significant correlations were found between MTT and DTI measures or between FA and any perfusion measure in the RRMS group. No significant correlations between diffusion and perfusion metrics were found in control subjects. CONCLUSION: In the normal-appearing corpus callosum of patients with RRMS, decreasing perfusion is correlated with decreasing MD. These findings are more consistent with what would be expected in primary ischemia than in secondary hypoperfusion from WD.

Item Type: Article
Uncontrolled Keywords: 0 (contrast media) k2i13dr72l,(gadolinium dtpa) ,adult blood flow velocity ,blood volume contrast media corpus callosum,blood supply ,diffusion magnetic resonance imaging female gadolinium dtpa,diagnostic use humans image processing,computer-assisted ,magnetic resonance imaging male middle aged multiple sclerosis,relapsing-remitting,physiopathology
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 18 Sep 2015 10:48
Last Modified: 12 Jul 2020 23:45
URI: https://ueaeprints.uea.ac.uk/id/eprint/54379
DOI:

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