Short-term DTI predictors of cognitive dysfunction in mild traumatic brain injury

Miles, Laura, Grossman, Robert I., Johnson, Glyn, Babb, James S., Diller, Leonard and Inglese, Matilde (2008) Short-term DTI predictors of cognitive dysfunction in mild traumatic brain injury. Brain Injury, 22 (2). pp. 115-22. ISSN 0269-9052

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PRIMARY OBJECTIVE: To explore whether baseline diffusion tensor imaging (DTI) metrics are predictive of cognitive functioning 6 months post-injury in patients with mild traumatic brain injury (MTBI). RESEARCH DESIGN: Seventeen patients with MTBI and 29 sex- and age-matched healthy controls were studied. METHODS AND PROCEDURES: Participants underwent an MRI protocol including DTI, at an average of 4.0 (range: 1-10) days post-injury. Mean diffusivity (MD) and fractional anisotropy (FA) were measured in the following white matter (WM) regions: centra semiovale, the genu and the splenium of the corpus callosum and the posterior limb of the internal capsule. Participants underwent neuropsychological (NP) testing at baseline and at 6-month follow-up. Least squares regression analysis was used to evaluate the association of MD and FA with each NP test score at baseline and follow-up. MAIN OUTCOMES AND RESULTS: Compared to controls, average MD was significantly higher (p = 0.02) and average FA significantly lower (p = 0.0001) in MTBI patients. At the follow-up, there was a trend toward a significant association between baseline MD and response speed (r = -0.53, p = 0.087) and a positive correlation between baseline FA and Prioritization form B (r = 0.72, p = 0.003). CONCLUSIONS: DTI may provide short-term non-invasive predictive markers of cognitive functioning in patients with MTBI.

Item Type: Article
Uncontrolled Keywords: *methods female humans image processing, computer-assisted male middle aged neuropsychological tests predictive value of tests,pathology brain injuries,complications case-control studies cognition disorders,diagnosis diffusion magnetic resonance imaging,methods female humans image processing,computer-assisted ,male middle aged ,neuropsychological ,tests predictive ,value of tests
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 17 Sep 2015 12:16
Last Modified: 21 Oct 2022 01:14
DOI: 10.1080/02699050801888816

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