Robust quantification of contrast agent (CA) concentration with magnetic field correlation (MFC) imaging

Patil, V., Johnson, G. and Jensen, J. H. (2009) Robust quantification of contrast agent (CA) concentration with magnetic field correlation (MFC) imaging. Journal of Magnetic Resonance Imaging, 62 (4). pp. 1002-6. ISSN 1522-2586

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Abstract

Contrast-enhanced perfusion studies of the brain by means magnetic resonance imaging (MRI) are used to estimate a number of important brain tissue parameters, including cerebral blood flow and volume. In order to calculate these parameters, the contrast agent (CA) concentration must first be estimated. This is usually accomplished by measurement of a nuclear magnetic resonance (NMR) relaxation rate with the assumption of a linear relationship between the rate and the CA concentration. However, such a linear relationship does not necessarily hold in biological tissues due to compartmentalization of the CA in either the intravascular or extracellular spaces. Here we propose an alternative MRI method of CA quantification based on measurement of the magnetic field correlation (MFC), which is theoretically predicted to have a robust quadratic dependence on the CA concentration even when the CA is compartmentalized. In this study, CA concentration estimation by means of MFC is shown to be more accurate than established methods based on relaxation rates in yeast cell suspensions.

Item Type:	Article
Uncontrolled Keywords:	0 (contrast media) ,k2i13dr72l (gadolinium dtpa), algorithms contrast media,pharmacokinetics electromagnetic fields gadolinium dtpa,diagnostic use,pharmacokinetics image interpretation ,computer-assisted,methods magnetic resonance imaging,methods magnetic resonance spectroscopy,methods reproducibility of results saccharomyces cerevisiae,cytology,metabolism sensitivity and specificity
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Norwich Clinical Trials Unit Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Depositing User:	Pure Connector
Date Deposited:	17 Sep 2015 13:26
Last Modified:	21 Oct 2022 01:14
URI:	https://ueaeprints.uea.ac.uk/id/eprint/54370
DOI:	10.1002/mrm.22099

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