DeltaR2 (*) gadolinium-diethylenetriaminepentacetic acid relaxivity in venous blood

Patil, V. and Johnson, G. (2013) DeltaR2 (*) gadolinium-diethylenetriaminepentacetic acid relaxivity in venous blood. Magnetic Resonance in Medicine, 69 (4). pp. 1104-1108. ISSN 0740-3194

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The accuracy of perfusion measurements using dynamic, susceptibility-weighted, contrast-enhanced MRI depends on estimating contrast agent concentration in an artery, i.e., the arterial input function. One of the difficulties associated with obtaining an arterial input function are partial volume effects when both blood and brain parenchyma occupy the same pixel. Previous studies have attempted to correct arterial input functions which suffer from partial volume effects using contrast concentration in venous blood. However, the relationship between relaxation and concentration (C) in venous blood has not been determined in vivo. In this note, a previously employed fitting approach is used to determine venous relaxivity in vivo. In vivo relaxivity is compared with venous relaxivity measured in vitro in bulk blood. The results show that the fitting approach produces relaxivity calibration curves which give excellent agreement with arterial measurements.

Item Type: Article
Additional Information: Patil, Vishal Johnson, Glyn eng R01 CA111996/CA/NCI NIH HHS/ R01CA111996/CA/NCI NIH HHS/ Research Support, N.I.H., Extramural 2012/05/12 06:00 Magn Reson Med. 2013 Apr;69(4):1104-8. doi: 10.1002/mrm.24331. Epub 2012 May 10.
Uncontrolled Keywords: relaxivity,venous,dynamic susceptibility ,contrast mri,perfusion
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 17 Aug 2015 15:58
Last Modified: 31 Oct 2022 11:31
DOI: 10.1002/mrm.24331

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