Giant cell arteritis—over diagnosed?

Yates, Max ORCID:, Pickup, Luke, Igali, Laszlo, Mukhtyar, Chetan ORCID:, Watts, Richard and Macgregor, Alexander ORCID: (2014) Giant cell arteritis—over diagnosed? In: UNSPECIFIED.

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Background: GCA is the most common vasculitis in the western world. It typically affects individuals >55 years of age and has significant morbidity from its pathology and its treatment. There are no recent (after 2001) estimates of the occurrence in the UK. The aim of this study was to estimate the occurrence of GCA in the UK. Methods: All temporal artery biopsies performed at the Norfolk and Norwich University hospital between 2003 and 2012 were reviewed. Cases of GCA were included only after careful case notes review with all cases fulfilling 1990 ACR criteria. The general practice (GP) location was noted for each of the included cases. The GP location was grouped into standard local authority boundaries. In cases where the individual practice population lay on a local authority boundary, the practice was classified into the local authority area which held the majority of the registered patients. The population denominator was calculated from national census data. Results: There were 601 temporal biopsies performed at the NNUH between the years 2003 and 2012. Subsequently 267 individuals were diagnosed with GCA (44%); 206 were biopsy positive cases (77.2%). The mean age at diagnosis was 75.4 years; 187 were women (70%). Patients with biopsy positive GCA were significantly older (mean difference 2.4 years CI 0.1, 4.7, P < 0.05) and had a statistically significantly higher ESR (mean difference 12 mm/h, CI 4, 21, P = 0.005) compared with individuals with biopsy negative disease. Incidence was calculated for the last 6 years of the study since robust data recording allowed for assured inclusion of cases of GCA with negative biopsy. There were 219 cases of GCA (61 biopsy negative—27.9%) diagnosed in this period (2007–2012). Seven cases of GCA came from practices within the local authority area of Great Yarmouth and one case from elsewhere. These were excluded from the analysis. Of the remaining 211 cases of GCA came from 72 general practices in five local authority areas. The incidence rate per 100 000 was 13.9 (95% CI 10.7, 25.3) in people aged >50 years. Conclusion: The results reveal and estimate of 13.9 per 100 000 people aged >50 years. This is much lower than the estimate from the GPRD study carried out in 2001. Within the GPRD study only three out of a selection of 45 cases that were reviewed had a positive temporal artery biopsy (6.7%) and 10 cases (22.2%) were diagnosed and managed in primary care alone. Assuming an incidence for our study is similar to that of the GPRD then in Norfolk perhaps as many as 50% of cases of GCA are managed in the community without undergoing biopsy before embarking on toxic corticosteroid treatment.

Item Type: Conference or Workshop Item (Other)
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Epidemiology and Public Health
Faculty of Medicine and Health Sciences > Research Groups > Musculoskeletal Medicine
Faculty of Medicine and Health Sciences > Research Groups > Nutrition and Preventive Medicine
Faculty of Medicine and Health Sciences > Research Groups > Public Health and Health Services Research (former - to 2023)
Faculty of Science > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Groups > Norwich Epidemiology Centre
Faculty of Medicine and Health Sciences > Research Centres > Population Health
Depositing User: Pure Connector
Date Deposited: 26 Aug 2015 15:08
Last Modified: 19 Oct 2023 03:59
DOI: 10.1093/rheumatology/keu210.009

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