Successful ceftolozane/tazobactam treatment of chronic pulmonary infection with pan‐resistant Pseudomonas aeruginosa

Soliman, Reham, Lynch, Sarah, Meader, Emma, Pike, Rachel, Turton, Jane F., Hill, Robert L.R., Woodford, Neil and Livermore, David (2015) Successful ceftolozane/tazobactam treatment of chronic pulmonary infection with pan‐resistant Pseudomonas aeruginosa. JMM Case Reports, 2. ISSN 2053-3721

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Abstract

The treatment of chronic Pseudomonas aeruginosa infections is challenging, with resistance and antibiogram diversity accumulating during successive therapies. Some isolates are resistant to all licensed agents, creating treatment problems and an urgent need for new therapies. Among antibiotics in advanced development, ceftolozane/tazobactam has potent in vitro antipseudomonal activity, with low MICs even for strains with AmpC β‐lactamase‐, impermeability‐ and efflux‐mediated resistance to other β‐lactams.

Item Type: Article
Additional Information: This is an open access article published by the Society for General Microbiology under the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/)
Uncontrolled Keywords: pseudomonas,pan‐resistance, aeruginosa, ceftolozane‐tazobactam,bronchiectasis
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Faculty of Science > School of Biological Sciences
Depositing User: Pure Connector
Date Deposited: 25 Aug 2015 09:24
Last Modified: 22 Jul 2020 00:22
URI: https://ueaeprints.uea.ac.uk/id/eprint/54042
DOI: 10.1099/jmmcr.0.000025

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