Progression of diabetes retinal status within community screening programmes and potential implications for screening intervals

Leese, Graham P., Stratton, Irene M., Land, Martin, Bachmann, Max O., Jones, Colin, Scanlon, Peter, Looker, Helen C. and Ferguson, Brian (2015) Progression of diabetes retinal status within community screening programmes and potential implications for screening intervals. Diabetes Care, 38 (3). pp. 488-494. ISSN 0149-5992

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Abstract

Objective This study aimed to follow the natural progression of retinal changes in patients with diabetes. Such information should inform decisions with regard to the screening intervals for such patients Research Design and Methods An observational study was undertaken linking the data from seven diabetes retinal screening programmes across the UK for retinal grading results between 2005 and 2012. Patients with absent or background retinopathy were followed up for progression to the endpoints referable retinopathy, and treatable retinopathy (proliferative retinopathy). Results In total 354,549 patients were observed for up to four years during which 16,196 progressed to referable retinopathy. Of patients with no retinopathy in either eye for two successive screening episodes at least 12 months apart between 0.3 (95% confidence interval 0.3-0.8)% and 1.3 (1.0-1.6)% progressed to referable retinopathy and rates of treatable eye disease were less than 0.3% at two years. The corresponding progression rates for patients with bilateral background retinopathy in successive screening episodes was 13-29% and up to 4% respectively in the different programmes. Conclusions It may be possible to risk stratify patients according to baseline retinal criteria into low and high risk of progressing to proliferative retinopathy. Screening intervals for such diverse groups of patients could safely be modified according to their risk,

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 24 Jul 2015 22:45
Last Modified: 07 May 2020 23:49
URI: https://ueaeprints.uea.ac.uk/id/eprint/53679
DOI: 10.2337/dc14-1778

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