Application of asymmetric C-­‐H activation to the synthesis of Planar Chiral Catalysts and Ligands.

Panchal, Ketan (2014) Application of asymmetric C-­‐H activation to the synthesis of Planar Chiral Catalysts and Ligands. Doctoral thesis, University of East Anglia.

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Abstract

The synthesis and application of ferrocene-­‐based palladacycles has been at the forefront of catalysis for a
number of years. The use of C-­‐H activation to synthesise
such compounds has been a relatively new development.
The work within this thesis attempts to develop on known
protocols devised by Richards et al. for the generation of
enantioenriched planar chiral palladacycles.1. The first of
which includes the synthesis and application of
symmetrical and non-­‐symmetrical phosphines, and in this
work the latter have been transformed into a diastereomerically pure enantiomerically enriched
palladacycle via a transcyclopalladation (Scheme I).
Compound 343 was generated as a diastereomerically
pure palladacycle in 96% ee, and the kinetic resolution
of the phosphine pre-­‐courser to 319 afforded a d.r. of
99:1 and a 76% ee. Finally, methods developed by Shu
Li-­‐You and Wu have been extended to a cobalt sandwich
complex affording novel bi-­‐substituted ligands (Scheme
II).2

Item Type: Thesis (Doctoral)
Faculty \ School: Faculty of Science > School of Chemistry
Depositing User: Brian Watkins
Date Deposited: 15 Jun 2015 13:34
Last Modified: 15 Jun 2015 13:36
URI: https://ueaeprints.uea.ac.uk/id/eprint/53358
DOI:

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