Effect of L-arginine on renal blood flow in normal subjects and patients with hypoxic chronic obstructive pulmonary disease

Howes, T Q, Keilty, S E, Maskrey, V L, Deane, C R, Baudouin, S V and Moxham, J (1996) Effect of L-arginine on renal blood flow in normal subjects and patients with hypoxic chronic obstructive pulmonary disease. Thorax, 51 (5). pp. 516-519. ISSN 0040-6376

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Abstract

L-arginine is the precursor of endothelium derived nitric oxide (NO) and increasing the available substrate may increase the production of NO. This has been shown by local infusion in peripheral vascular beds but there are few studies of the effects during systemic infusion. Renal vasoconstriction is known to be important in the pathogenesis of cor pulmonale in patients with hypoxic chronic obstructive pulmonary disease (COPD). The effects of a systemic infusion of L-arginine on renal and aortic haemodynamics were therefore investigated in normal subjects and in patients with hypoxic COPD.

Item Type: Article
Uncontrolled Keywords: aged,anoxia,aorta,arginine,blood flow velocity,blood pressure,case-control studies,double-blind method,heart rate,humans,infusions, intravenous,kidney,lung diseases, obstructive,middle aged,renal circulation,ultrasonography, doppler, color
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 30 Apr 2015 12:32
Last Modified: 22 Apr 2020 00:07
URI: https://ueaeprints.uea.ac.uk/id/eprint/53214
DOI: 10.1136/thx.51.5.516

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