Aspartame pharmacokinetics - the effect of ageing

Puthrasingam, S, Heybroek, W M, Johnston, A, Maskrey, V, Swift, C G, Turner, P, Abrams, S M and Jackson, S H (1996) Aspartame pharmacokinetics - the effect of ageing. Age and Ageing, 25 (3). pp. 217-220. ISSN 0002-0729

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Abstract

Aspartame is an intense sweetener which is increasingly used in the UK. It is registered at an acceptable daily intake (ADI) of 40 mg/kg, although there are no previous data relating to the metabolism of aspartame in older people. Twelve young and 12 elderly volunteers each received a single dose of approximately 40 mg/kg of aspartame. Baseline concentrations of phenylalanine (the main metabolite of aspartame) rose after ingestion with a significantly higher maximum concentration (Cmax) (81.3 vs. 63.3 micromol/1, p

Item Type: Article
Uncontrolled Keywords: adult,aged,aged, 80 and over,aging,aspartame,female,humans,male,metabolic clearance rate,phenylalanine,pilot projects,reference values
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 30 Apr 2015 12:32
Last Modified: 22 Apr 2020 00:07
URI: https://ueaeprints.uea.ac.uk/id/eprint/53213
DOI: 10.1093/ageing/25.3.217

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