Matrix metalloproteinases and diseases of the CNS

Yong, Voon Wee, Forsyth, Peter A., Krekoski, Craig A., Bell, Robert and Edwards, Dylan R. ORCID: (1998) Matrix metalloproteinases and diseases of the CNS. Trends in Neurosciences, 21 (2). pp. 75-80. ISSN 0166-2236

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Matrix metalloproteinases (MMPs) are increasingly being implicated in the pathogenesis of several CNS diseases. In multiple sclerosis, MMPs could be responsible for the influx of inflammatory mononuclear cells into the CNS, contribute to myelin destruction and disrupt the integrity of the blood-brain barrier; in Alzheimer's disease, MMPs might mediate the deposition of amyloid beta-proteins; and MMPs are known to contribute to the invasiveness of malignant glioma cells and might regulate their angiogenic capacity. Nonetheless, MMPs could also have beneficial roles in recovery from CNS injury.Therefore, both the identity of the MMP and its cellular origin could determine whether disease pathogenesis or regeneration occurs, and thus synthetic MMP inhibitors might be valuable for treating some CNS diseases.

Item Type: Article
Uncontrolled Keywords: animals,central nervous system diseases,extracellular matrix,humans,metalloendopeptidases
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Cells and Tissues
Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Depositing User: Pure Connector
Date Deposited: 25 Mar 2015 13:48
Last Modified: 19 Apr 2023 00:36
DOI: 10.1016/S0166-2236(97)01169-7

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