High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma

Forsyth, P A, Laing, T D, Gibson, A W, Rewcastle, N B, Brasher, P, Sutherland, G, Johnston, R N and Edwards, D R ORCID: https://orcid.org/0000-0002-3292-2064 (1998) High levels of gelatinase-B and active gelatinase-A in metastatic glioblastoma. Journal of Neuro-Oncology, 36 (1). pp. 21-29. ISSN 0167-594X

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Extra-neural metastases from glioblastoma multiforme (GBM) are rare. Because gelatinases-A and -B have been implicated in tumor invasion/metastasis in non-neural tumors, we compared the expression of gelatinase-A and -B in 2 patients (both had a prior craniotomy performed) with extraneural metastases from GBM to expression levels in 24 other gliomas; 15 non-metastatic GBMs, 9 other lower grade gliomas, and 7 normal brain tissues.

Item Type: Article
Uncontrolled Keywords: adult,brain neoplasms,collagenases,enzyme activation,fatal outcome,gelatinases,glioblastoma,head and neck neoplasms,humans,lymphatic metastasis,male,matrix metalloproteinase 2,matrix metalloproteinase 9,metalloendopeptidases,orbital neoplasms,skull neoplasms,tracheal neoplasms
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Cells and Tissues
Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Depositing User: Pure Connector
Date Deposited: 25 Mar 2015 13:44
Last Modified: 19 Apr 2023 00:36
URI: https://ueaeprints.uea.ac.uk/id/eprint/52956
DOI: 10.1023/A:1005879027267

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