New insights into the plasticity of the endothelial phenotype

Cooley, Lindsay S and Edwards, Dylan R ORCID: (2011) New insights into the plasticity of the endothelial phenotype. Biochemical Society Transactions, 39 (6). pp. 1639-1643. ISSN 0300-5127

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The mammalian vascular system consists of two distinct, but closely related, networks: the blood vasculature (itself divided into arterial and venous networks) and the lymphatic vasculature. EC (endothelial cell) lineage specification has been proposed to be determined during embryonic development, after which the ECs are committed to their fate. However, increasing evidence suggests that ECs retain various degrees of plasticity, and have the ability to express characteristics of alternative cell lineages. Therapeutic control of endothelial plasticity will allow greater understanding of the genesis and treatment of several vascular diseases.

Item Type: Article
Uncontrolled Keywords: animals,blood vessels,cell lineage,endothelial cells,humans,lymphatic vessels,models, biological,phenotype
Faculty \ School: Faculty of Science > School of Biological Sciences
UEA Research Groups: Faculty of Science > Research Groups > Cells and Tissues
Faculty of Medicine and Health Sciences > Research Groups > Cancer Studies
Depositing User: Pure Connector
Date Deposited: 25 Mar 2015 13:28
Last Modified: 19 Apr 2023 00:36
DOI: 10.1042/BST20110723

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