Human arterial responses to isometric exercise:the role of the muscle metaboreflex

Davies, Tom S, Frenneaux, Michael P, Campbell, Ross I and White, Michael J (2007) Human arterial responses to isometric exercise:the role of the muscle metaboreflex. Clinical Science, 112 (8). pp. 441-7. ISSN 1470-8736

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The effects of exercise on the distensibility of large and medium-sized arteries are poorly understood, but can be attributed to a combination of local vasodilator effects of exercise opposed by sympathetic vasoconstrictor tone. We sought to examine this relationship at the conduit artery level, with particular reference to the role of the sympatho-excitatory muscle metaboreflex. The effect of maintained muscle metaboreflex activation on a previously passive or exercised limb femoral artery was investigated. A total of ten healthy volunteers performed 2 min of isometric ankle plantar-flexion at 40% MVC (maximal voluntary force), in conjunction with 2 min of either non-ischaemic isometric HG (handgrip; control condition) or IHG (ischaemic HG) at 40% MVC. IHG was followed by 2 min of PECO (post-exercise circulatory occlusion) to maintain muscle metaboreflex activation. FTPWV [femoral-tibial PWV (pulse wave velocity)] was measured in the exercised or contralateral limb at baseline and immediately following calf exercise. BP (blood pressure) and HR (heart rate) were measured continuously throughout. In the HG condition, BP and HR returned promptly to baseline post-exercise, whereas exercised leg FTPWV was decreased (less stiff) by 0.6 m/s (P

Item Type: Article
Uncontrolled Keywords: adult,analysis of variance,ankle,blood pressure,case-control studies,exercise,exercise therapy,female,femoral artery,hand strength,humans,ischemia,isometric contraction,male,muscles,reflex,regional blood flow,vasodilation
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User: Pure Connector
Date Deposited: 23 Mar 2015 13:14
Last Modified: 23 Apr 2023 01:03
DOI: 10.1042/CS20060276

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