Nitrate and nitrite in biology, nutrition and therapeutics

Lundberg, Jon O, Gladwin, Mark T, Ahluwalia, Amrita, Benjamin, Nigel, Bryan, Nathan S, Butler, Anthony, Cabrales, Pedro, Fago, Angela, Feelisch, Martin, Ford, Peter C, Freeman, Bruce A, Frenneaux, Michael, Friedman, Joel, Kelm, Malte, Kevil, Christopher G, Kim-Shapiro, Daniel B, Kozlov, Andrey V, Lancaster, Jack R, Lefer, David J, McColl, Kenneth, McCurry, Kenneth, Patel, Rakesh P, Petersson, Joel, Rassaf, Tienush, Reutov, Valentin P, Richter-Addo, George B, Schechter, Alan, Shiva, Sruti, Tsuchiya, Koichiro, van Faassen, Ernst E, Webb, Andrew J, Zuckerbraun, Brian S, Zweier, Jay L and Weitzberg, Eddie (2009) Nitrate and nitrite in biology, nutrition and therapeutics. Nature Chemical Biology, 5 (12). pp. 865-869. ISSN 1552-4450

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Abstract

Inorganic nitrate and nitrite from endogenous or dietary sources are metabolized in vivo to nitric oxide (NO) and other bioactive nitrogen oxides. The nitrate-nitrite-NO pathway is emerging as an important mediator of blood flow regulation, cell signaling, energetics and tissue responses to hypoxia. The latest advances in our understanding of the biochemistry, physiology and therapeutics of nitrate, nitrite and NO were discussed during a recent 2-day meeting at the Nobel Forum, Karolinska Institutet in Stockholm.

Item Type: Article
Uncontrolled Keywords: animals,diet,energy metabolism,humans,mitochondria,nitrates,nitric oxide,nitrites,signal transduction
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 23 Mar 2015 13:10
Last Modified: 21 Apr 2020 23:59
URI: https://ueaeprints.uea.ac.uk/id/eprint/52800
DOI: 10.1038/nchembio.260

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