The pathophysiology of diastolic heart failure

Phan, Thanh Trung and Frenneaux, Michael (2010) The pathophysiology of diastolic heart failure. F1000 Biology Reports, 2. ISSN 1757-594X

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Whilst resting disturbances of both diastolic and long-axis systolic function are observed in patients with heart failure who have normal left ventricular ejection fraction, recent evidence suggests that dynamic disturbances in cardiac function occur during exercise. A paradoxical slowing of left ventricular active relaxation during exercise limits cardiac filling and therefore stroke volume and appears to be due to the combination of cardiac energetic impairment and disturbed ventricular-vascular coupling.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User: Pure Connector
Date Deposited: 23 Mar 2015 12:54
Last Modified: 23 Apr 2023 01:03
DOI: 10.3410/B2-16

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