The role of vascular myoglobin in nitrite-mediated blood vessel relaxation

Ormerod, Julian O M, Ashrafian, Houman, Maher, Abdul R, Arif, Sayqa, Steeples, Violetta, Born, Gustav V R, Egginton, Stuart, Feelisch, Martin, Watkins, Hugh and Frenneaux, Michael P (2011) The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Cardiovascular Research, 89 (3). pp. 560-5. ISSN 0008-6363

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This work investigates the role of myoglobin in mediating the vascular relaxation induced by nitrite. Nitrite, previously considered an inert by-product of nitric oxide metabolism, is now believed to play an important role in several areas of pharmacology and physiology. Myoglobin can act as a nitrite reductase in the heart, where it is plentiful, but it is present at a far lower level in vascular smooth muscle-indeed, its existence in the vessel wall is controversial. Haem proteins have been postulated to be important in nitrite-induced vasodilation, but the specific role of myoglobin is unknown. The current study was designed to confirm the presence of myoglobin in murine aortic tissue and to test the hypothesis that vascular wall myoglobin is important for nitrite-induced vasodilation.

Item Type: Article
Uncontrolled Keywords: animals,aorta,carbon monoxide,drug interactions,male,mice,mice, knockout,muscle, smooth, vascular,myoglobin,nitric oxide,nitric oxide donors,nitrite reductases,nitrites,nitroprusside,vasodilation
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User: Pure Connector
Date Deposited: 23 Mar 2015 12:54
Last Modified: 23 Apr 2023 01:03
DOI: 10.1093/cvr/cvq299

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