Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy:results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial

Howell, Neil J, Ashrafian, Houman, Drury, Nigel E, Ranasinghe, Aaron M, Contractor, Hussain, Isackson, Henrik, Calvert, Melanie, Williams, Lynne K, Freemantle, Nick, Quinn, David W, Green, David, Frenneaux, Michael, Bonser, Robert S, Mascaro, Jorge G, Graham, Timothy R, Rooney, Stephen J, Wilson, Ian C and Pagano, Domenico (2011) Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy:results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial. Circulation, 123 (2). pp. 170-7. ISSN 0009-7322

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Abstract

Patients undergoing aortic valve replacement for critical aortic stenosis often have significant left ventricular hypertrophy. Left ventricular hypertrophy has been identified as an independent predictor of poor outcome after aortic valve replacement as a result of a combination of maladaptive myocardial changes and inadequate myocardial protection at the time of surgery. Glucose-insulin-potassium (GIK) is a potentially useful adjunct to myocardial protection. This study was designed to evaluate the effects of GIK infusion in patients undergoing aortic valve replacement surgery.

Item Type: Article
Uncontrolled Keywords: amp-activated protein kinases,acetylglucosamine,aged,aortic valve,aortic valve stenosis,cardiac output, low,double-blind method,female,glucose,heart valve prosthesis,humans,hypertrophy, left ventricular,incidence,insulin,male,middle aged,phosphatidylinositol 3-kinases,potassium,proto-oncogene proteins c-akt,risk factors,treatment outcome
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 23 Mar 2015 12:48
Last Modified: 21 Apr 2020 23:59
URI: https://ueaeprints.uea.ac.uk/id/eprint/52788
DOI: 10.1161/CIRCULATIONAHA.110.945170

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