Antioxidant treatment for heart failure:friend or foe?

Thomson, M J, Frenneaux, M P and Kaski, J C (2009) Antioxidant treatment for heart failure:friend or foe? QJM, 102 (5). pp. 305-310. ISSN 1460-2725

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Increasing studies demonstrate a pivotal role for oxidant stress in the pathophysiology of heart failure (HF). Recent meta-analyses also reveal the potential pitfall of a mono-dimensional antioxidant approach. This review article summarizes the main biological pathways involved in oxidant stress and HF, the possible deleterious nature of certain antioxidant monotherapy and proposes potential antioxidant strategies necessary to challenge specific HF aetiology and progression.

Item Type: Article
Uncontrolled Keywords: animals,antioxidants,heart failure,humans,isoenzymes,mice,nitric oxide,nitric oxide synthase,oxidative stress,vitamin e
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 17 Mar 2015 12:16
Last Modified: 23 Apr 2023 01:03
DOI: 10.1093/qjmed/hcn160

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