What is treatment success in cardiac resynchronization therapy?

Foley, Paul W X, Leyva, Francisco and Frenneaux, Michael P (2009) What is treatment success in cardiac resynchronization therapy? EP-Europace, 11 Suppl 5. v58-65. ISSN 1099-5129

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Abstract

Cardiac resynchronization therapy (CRT) is an established treatment for symptomatic patients with heart failure, a prolonged QRS duration, and impaired left ventricular (LV) function. Identification of 'responders' and 'non-responders' to CRT has attracted considerable attention. The response to CRT can be measured in terms of symptomatic response or clinical outcome, or both. Alternatively, the response to CRT can be measured in terms of changes in surrogate measures of outcome, such as LV volumes, LV ejection fraction, invasive measures of cardiac performance, peak oxygen uptake, and neurohormones. This review explores whether these measures can be used in assessing the symptomatic and prognostic response to CRT. The role of these parameters to the management of individual patients is also discussed.

Item Type: Article
Uncontrolled Keywords: adult,aged,aged, 80 and over,cardiac pacing, artificial,heart failure,humans,middle aged,oxygen consumption,prognosis,stroke volume,treatment outcome,ventricular function, left,ventricular remodeling
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 17 Mar 2015 11:24
Last Modified: 21 Apr 2020 23:59
URI: https://ueaeprints.uea.ac.uk/id/eprint/52761
DOI: 10.1093/europace/eup308

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