Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy

Foley, Paul W X, Stegemann, Berthold, Ng, Kelvin, Ramachandran, Sud, Proudler, Anthony, Frenneaux, Michael P, Ng, Leong L and Leyva, Francisco (2009) Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy. European Heart Journal, 30 (22). pp. 2749-2757. ISSN 0195-668X

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Abstract

The aim of this study was to determine whether growth differentiation factor-15 (GDF-15) predicts mortality and morbidity after cardiac resynchronization therapy (CRT). Growth differentiation factor-15, a transforming growth factor-beta-related cytokine which is up-regulated in cardiomyocytes via multiple stress pathways, predicts mortality in patients with heart failure treated pharmacologically.

Item Type: Article
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Uncontrolled Keywords: aged,area under curve,biological markers,cardiac pacing, artificial,defibrillators, implantable,enzyme-linked immunosorbent assay,female,growth differentiation factor 15,heart failure,humans,male,middle aged,natriuretic peptide, brain,peptide fragments,risk factors,survival analysis
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 17 Mar 2015 11:20
Last Modified: 05 Jan 2023 16:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/52760
DOI: 10.1093/eurheartj/ehp300

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