Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy

Foley, Paul W X, Stegemann, Berthold, Ng, Kelvin, Ramachandran, Sud, Proudler, Anthony, Frenneaux, Michael P, Ng, Leong L and Leyva, Francisco (2009) Growth differentiation factor-15 predicts mortality and morbidity after cardiac resynchronization therapy. European Heart Journal, 30 (22). pp. 2749-2757. ISSN 0195-668X

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Abstract

The aim of this study was to determine whether growth differentiation factor-15 (GDF-15) predicts mortality and morbidity after cardiac resynchronization therapy (CRT). Growth differentiation factor-15, a transforming growth factor-beta-related cytokine which is up-regulated in cardiomyocytes via multiple stress pathways, predicts mortality in patients with heart failure treated pharmacologically.

Item Type:	Article
Additional Information:	The online version of this article has been published by OUP under an open access model. Users are entitled to use, reproduce, disseminate, or display the open access version of this article for non-commercial purposes provided that the original authorship is properly and fully attributed; the Journal, Learned Society and Oxford University Press are attributed as the original place of publication with correct citation details given; if an article is subsequently reproduced or disseminated not in its entirety but only in part or as a derivative work this must be clearly indicated. For commercial re-use, please contact journals.permissions@oxfordjournals.org
Uncontrolled Keywords:	aged,area under curve,biological markers,cardiac pacing, artificial,defibrillators, implantable,enzyme-linked immunosorbent assay,female,growth differentiation factor 15,heart failure,humans,male,middle aged,natriuretic peptide, brain,peptide fragments,risk factors,survival analysis
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	17 Mar 2015 11:20
Last Modified:	28 Mar 2025 06:31
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52760
DOI:	10.1093/eurheartj/ehp300

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