Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients

Nassimizadeh, Mohammad, Ashrafian, Houman, Drury, Nigel E, Howell, Neil J, Digby, Janet, Pagano, Domenico, Frenneaux, Michael P and Born, Gustav V R (2010) Reduced negative surface charge on arterial endothelium explains accelerated atherosclerosis in type 2 diabetic patients. Diabetes & Vascular Disease Research, 7 (3). pp. 213-5. ISSN 1479-1641

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Abstract

Reduced endothelial surface charge markedly increases the rate of LDL uptake into blood vessels. Previous work in the streptozotocin diabetic rat reported reduced endothelial surface charge. We compared endothelial surface charge density in internal mammary artery rings from patients with type 2 diabetes (n = 12) and from non diabetic patients undergoing coronary artery bypass grafting, and observed a substantial (52%) reduction in the former. This was associated with higher plasma sialic acid levels suggesting loss of sialic acid residues from the glycocalyx as a possible mechanism.

Item Type: Article
Uncontrolled Keywords: case-control studies,diabetes mellitus, type 2,diabetic angiopathies,endothelium, vascular,ferritins,glycocalyx,humans,mammary arteries,microscopy, electron,n-acetylneuraminic acid,staining and labeling,surface properties
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 17 Mar 2015 06:38
Last Modified: 21 Apr 2020 23:58
URI: https://ueaeprints.uea.ac.uk/id/eprint/52672
DOI: 10.1177/1479164110376207

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