Pathophysiology of coronary artery disease:the case for multiparametric imaging

Gamble, James H P, Scott, Gemma, Ormerod, Julian O M and Frenneaux, Michael P (2009) Pathophysiology of coronary artery disease:the case for multiparametric imaging. Expert Review of Cardiovascular Therapy, 7 (3). pp. 299-310. ISSN 1477-9072

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Interventions to treat coronary artery disease are available but they must be targeted at the correct individuals (and indeed lesions), in order to gain maximal benefit with the minimal adverse effects. Coronary contrast angiography is not able to provide all the information required for the assessment of the effects of artery disease. Other imaging modalities are of growing importance as they can reduce radiation exposure and invasiveness of screening, as well as providing important extra information. The ideal 'multiparametric' imaging technique would assess anatomy, viability and lesion activity in a single quick scan. Currently, MRI is the technology closest to achieving this ideal, although the existing technology still has some limitations. This review discusses the currently available techniques for the imaging of coronary anatomy and of myocardial viability, and considers their benefits and limitations. We also discuss the developing field of imaging molecularly targeted to active coronary lesions. Finally we provide a 5-year view of the current and likely future optimal imaging strategies.

Item Type: Article
Uncontrolled Keywords: clinical trials as topic,coronary angiography,coronary artery disease,humans,magnetic resonance angiography,magnetic resonance imaging,positron-emission tomography,tomography, emission-computed, single-photon
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User: Pure Connector
Date Deposited: 13 Mar 2015 16:46
Last Modified: 23 Apr 2023 01:01
DOI: 10.1586/14779072.7.3.299

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