Effects of aldosterone on forearm vasculature in treated chronic heart failure

Gunaruwan, Prasad, Schmitt, Matthias, Sharman, James, Lee, Leong, Struthers, Alan and Frenneaux, Michael (2005) Effects of aldosterone on forearm vasculature in treated chronic heart failure. The American Journal of Cardiology, 95 (3). pp. 412-4. ISSN 0002-9149

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Abstract

The nongenomic effects of aldosterone in disease states associated with endothelial dysfunction may differ from those in healthy subjects. The effects of locally infused aldosterone on the forearm blood flow and volume were studied in optimally treated patients with chronic heart failure (CHF). At baseline and after incremental intrabrachial aldosterone, forearm blood flow was assessed using conventional strain gauge plethysmography, and forearm venous volume was assessed by radionuclide plethysmography. Constriction of the resistance vasculature of the forearm without significant effect on forearm venous capacitance was demonstrated in response to aldosterone in patients treated for CHF.

Item Type: Article
Uncontrolled Keywords: aged,aldosterone,analysis of variance,blood flow velocity,dose-response relationship, drug,female,forearm,heart failure,humans,infusions, intra-arterial,male,regional blood flow,vascular resistance
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 13 Mar 2015 16:26
Last Modified: 21 Apr 2020 23:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/52638
DOI: 10.1016/j.amjcard.2004.09.047

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