Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure

Schmitt, Matthias, Gunaruwan, Prasad, Payne, Nicola, Taylor, Justin, Lee, Leong, Broadley, Andrew J M, Nightingale, Angus K, Cockcroft, John R, Struthers, Allan D, Tyberg, John V and Frenneaux, Michael P (2004) Effects of exogenous and endogenous natriuretic peptides on forearm vascular function in chronic heart failure. Arteriosclerosis, Thrombosis, and Vascular Biology, 24 (5). pp. 911-7. ISSN 1079-5642

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Abstract

Natriuretic peptides (NPs) reduce central venous pressure in patients with chronic heart failure (cHF) despite attenuation of arterial, renal, and humoral effects. This suggests a preserved venodilator response. This study had 4 aims: to compare the venodilator effects of human NPs in patients with cHF; to assess the contribution of basal ANP and BNP levels to regulation of forearm vascular volume (FVV); to test the hypothesis that venous ANP responsiveness is preserved in cHF; and to assess the involvement of endothelial nitric oxide-synthase (eNOS) in NP-induced vascular effects.

Item Type: Article
Uncontrolled Keywords: adult,aged,aged, 80 and over,arteries,atrial natriuretic factor,cardiovascular agents,cyclic gmp,endothelium, vascular,enzyme inhibitors,female,forearm,heart failure,humans,injections, intra-arterial,male,middle aged,natriuretic peptide, brain,natriuretic peptide, c-type,natriuretic peptides,nitric oxide,nitric oxide synthase,nitric oxide synthase type iii,peptide fragments,tetrahydroisoquinolines,vascular resistance,vasodilation,veins,omega-n-methylarginine
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 13 Mar 2015 16:20
Last Modified: 21 Apr 2020 23:57
URI: https://ueaeprints.uea.ac.uk/id/eprint/52626
DOI: 10.1161/01.ATV.zhq0504.7914

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