Changes in pulmonary vascular function after acute methionine loading in normal men

O'Dochartaigh, Conor, Ong, Hean, Lovell, Sharon, Donnelly, Ronan, Hanratty, Colm, Riley, Marshall, Frenneaux, Michael, Young, Ian and Nicholls, Paul (2004) Changes in pulmonary vascular function after acute methionine loading in normal men. Clinical Science, 106 (4). pp. 413-419. ISSN 0143-5221

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Elevated blood levels of Hcy (homocysteine) are associated with endothelial dysfunction in the systemic and coronary arterial beds. We wished to know if similar changes could be detected in the pulmonary circulation, using non-invasive tests. We studied ten normal young men aged 23-31 years, in whom acute hyperhomocysteinaemia was induced by oral ingestion of methionine. Cardiopulmonary exercise testing [including measurement of exhaled breath NO (nitric oxide)] was performed on two occasions, with and without methionine loading. In addition, blood samples for vWf (von Willebrand factor) and factor VIIIc were taken as markers of endothelial function. After oral methionine, plasma Hcy increased from 11.8 +/- 3.1 to 31.2 +/- 10.3 micromol/l (values are means +/- S.D.; P

Item Type: Article
Uncontrolled Keywords: adult,biological markers,breath tests,endothelium, vascular,exercise test,factor viii,humans,hyperhomocysteinemia,male,methionine,nitric oxide,pulmonary circulation,pulmonary gas exchange,von willebrand factor
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User: Pure Connector
Date Deposited: 13 Mar 2015 16:20
Last Modified: 23 Apr 2023 01:01
DOI: 10.1042/CS20030383

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