Inhibition of platelet aggregation by nitric oxide donors improves with rest

Broadley, Andrew J M, Schmitt, Matthias and Frenneaux, Michael P (2003) Inhibition of platelet aggregation by nitric oxide donors improves with rest. Platelets, 14 (6). pp. 347-349. ISSN 0953-7104

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It has been suggested that the platelets of patients with acute coronary syndromes (ACS) exist in a more activated state than those of patients with stable coronary heart disease (CHD) or healthy individuals. "Platelet nitrate responsiveness" (PNR) has been suggested as a measure of platelet activation, and has been shown to be reduced in both ACS and stable CHD. We examined the effect of a short period of undisturbed supine rest, an intervention aimed at reducing levels of "stress", on PNR. In 8 healthy subjects we found that 45 minutes of rest led to a highly significant reduction in platelet aggregation and increase in PNR. Our finding supports the hypothesis that stress contributes to platelet activation as reflected in reduced PNR, which may contribute to the link between acute stress and cardiovascular events. It also emphasises that standardisation of sampling conditions in vitally important in studies utilizing PNR.

Item Type: Article
Uncontrolled Keywords: blood platelets,humans,nitrates,nitric oxide donors,nitroprusside,platelet aggregation,platelet aggregation inhibitors
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User: Pure Connector
Date Deposited: 25 Feb 2015 06:16
Last Modified: 23 Apr 2023 01:00
DOI: 10.1080/09537100310001603623

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