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ToolsEvans, M, Anderson, R A, Smith, J C, Khan, N, Graham, J M, Thomas, A W, Morris, K, Deely, D, Frenneaux, M P, Davies, J S and Rees, A (2003) Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus. European Journal of Clinical Investigation, 33 (3). pp. 231-8. ISSN 0014-2972
Full text not available from this repository.Abstract
Insulin therapy may influence cardiovascular disease (CVD) and lipid metabolism in type 2 diabetes (T2D). Exaggerated postprandial lipaemia (PPL) is a feature of diabetic dyslipidaemia affecting CVD via enhanced oxidative stress (OS) and endothelial dysfunction. We assessed endothelial function and OS during PPL following insulin and vitamin C. Twenty (17 M) T2D patients were studied (mean Hba1c 8.4%) at baseline, following 6 weeks of insulin lispro (0.2 Iu kg-1) and vitamin C 1-g daily. Eight-h lipid and glucose profiles were measured following a fatty meal. Endothelial function (flow-mediated vasodilatation: FMD) and OS were measured at fasting, 4 h and 8 h.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | adult,ascorbic acid,cardiovascular diseases,diabetes mellitus, type 2,endothelium, vascular,female,humans,hyperlipidemias,hypoglycemic agents,insulin,insulin lispro,male,middle aged,oxidative stress,postprandial period,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being |
| Faculty \ School: | Faculty of Medicine and Health Sciences > Norwich Medical School |
| UEA Research Groups: | Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health |
| Depositing User: | Pure Connector |
| Date Deposited: | 09 Mar 2015 07:30 |
| Last Modified: | 23 Apr 2023 00:59 |
| URI: | https://ueaeprints.uea.ac.uk/id/eprint/52454 |
| DOI: | 10.1046/j.1365-2362.2003.01120.x |
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