Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus

Evans, M, Anderson, R A, Smith, J C, Khan, N, Graham, J M, Thomas, A W, Morris, K, Deely, D, Frenneaux, M P, Davies, J S and Rees, A (2003) Effects of insulin lispro and chronic vitamin C therapy on postprandial lipaemia, oxidative stress and endothelial function in patients with type 2 diabetes mellitus. European Journal of Clinical Investigation, 33 (3). pp. 231-8. ISSN 0014-2972

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Abstract

Insulin therapy may influence cardiovascular disease (CVD) and lipid metabolism in type 2 diabetes (T2D). Exaggerated postprandial lipaemia (PPL) is a feature of diabetic dyslipidaemia affecting CVD via enhanced oxidative stress (OS) and endothelial dysfunction. We assessed endothelial function and OS during PPL following insulin and vitamin C. Twenty (17 M) T2D patients were studied (mean Hba1c 8.4%) at baseline, following 6 weeks of insulin lispro (0.2 Iu kg-1) and vitamin C 1-g daily. Eight-h lipid and glucose profiles were measured following a fatty meal. Endothelial function (flow-mediated vasodilatation: FMD) and OS were measured at fasting, 4 h and 8 h.

Item Type: Article
Uncontrolled Keywords: adult,ascorbic acid,cardiovascular diseases,diabetes mellitus, type 2,endothelium, vascular,female,humans,hyperlipidemias,hypoglycemic agents,insulin,insulin lispro,male,middle aged,oxidative stress,postprandial period
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 09 Mar 2015 07:30
Last Modified: 21 Apr 2020 23:54
URI: https://ueaeprints.uea.ac.uk/id/eprint/52454
DOI: 10.1046/j.1365-2362.2003.01120.x

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