Diastolic ventricular interaction and ventricular diastolic filling

Morris-Thurgood, Jayne A. and Frenneaux, Michael P. (2000) Diastolic ventricular interaction and ventricular diastolic filling. Heart Failure Reviews, 5 (4). pp. 307-323. ISSN 1382-4147

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Because the ventricles share a common septum, the filling of one may influence the compliance of the other, a phenomenon known as direct diastolic ventricular interaction (DVI). This interaction is markedly enhanced when the force exerted by the surrounding pericardium is raised (pericardial constraint). In health, in the resting state, we operate near the top of the flat component of a J-shaped pericardial stress-strain relation. Therefore, pericardial constraint (and hence DVI) is only minor. When right ventricular volume/pressure acutely increases, such as during exercise, massive pulmonary embolism, or right ventricular infarction, pericardial constraint increases and significant DVI develops. In this setting, the measured left ventricular intracavitary diastolic pressure markedly overestimates the true left ventricular filling pressure, because the external forces must be subtracted. Although the pericardium can grow during chronic cardiac enlargement, we present evidence that in certain chronic disease processes, including heart failure, DVI may also be important.

Item Type: Article
Uncontrolled Keywords: animals,blood pressure,diastole,dogs,heart diseases,humans,hypertension, pulmonary,pericardium,ventricular function, left,ventricular function, right
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User: Pure Connector
Date Deposited: 09 Mar 2015 07:29
Last Modified: 09 Aug 2023 10:30
URI: https://ueaeprints.uea.ac.uk/id/eprint/52433
DOI: 10.1023/A:1026555012135

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