Acute effects of vitamin C on platelet responsiveness to nitric oxide donors and endothelial function in patients with chronic heart failure

Ellis, Gethin R., Anderson, Richard A., Chirkov, Yuliy Y., Morris-Thurgood, Jayne, Jackson, Simon K., Lewis, Malcolm J., Horowitz, John D. and Frenneaux, Michael P. (2001) Acute effects of vitamin C on platelet responsiveness to nitric oxide donors and endothelial function in patients with chronic heart failure. Journal of Cardiovascular Pharmacology, 37 (5). pp. 564-570. ISSN 0160-2446

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Abstract

Chronic heart failure (CHF) is characterized by a prothrombotic state, which may relate to increased platelet aggregability, endothelial dysfunction, and increased oxidative stress. We investigated the effect of vitamin C in CHF on ex vivo platelet aggregation and platelet responsiveness to the anti-aggregatory effects of the nitric oxide (NO) donors glyceryl trinitrate (GTN) and sodium nitroprusside (SNP). We also examined parameters of oxidative stress and endothelial function in patients. In this double-blind, randomized, crossover study vitamin C (2 g) or placebo was given intravenously to 10 patients with CHF. We measured adenosine 5-diphosphate (ADP)-induced platelet aggregation, flow-mediated dilatation (FMD) in the brachial artery using ultrasonic wall-tracking, and plasma levels of lipid-derived free radicals using electron paramagnetic resonance spectroscopy. Vitamin C did not affect ex vivo platelet aggregability but enhanced the inhibition of platelet aggregation by SNP (62.7+/-10.2 to 82.7+/-4.8%, p = 0.03) and tended to increase responses to GTN (40.5+/-9.0 to 53.4+/-7.3, p = 0.06). The effect of vitamin C on platelet responsiveness to the antiaggregatory effects of SNP was inversely related to basal response to SNP (r = -0.9, p

Item Type: Article
Uncontrolled Keywords: adult,aged,analysis of variance,antioxidants,ascorbic acid,chronic disease,cross-over studies,double-blind method,endothelium, vascular,female,heart failure,humans,linear models,male,middle aged,nitric oxide donors,nitroglycerin,nitroprusside,oxidative stress,platelet aggregation,vasodilator agents
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
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Depositing User: Pure Connector
Date Deposited: 09 Mar 2015 07:29
Last Modified: 21 Apr 2020 23:54
URI: https://ueaeprints.uea.ac.uk/id/eprint/52432
DOI:

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