Abnormal metabolic fate of nitric oxide in Type I diabetes mellitus

Milsom, A B, Jones, C J H, Goodfellow, J, Frenneaux, M P, Peters, J R and James, P E (2002) Abnormal metabolic fate of nitric oxide in Type I diabetes mellitus. Diabetologia, 45 (11). pp. 1515-22. ISSN 0012-186X

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Abstract

Reduced bioavailability of endothelium-derived nitric oxide is implicated in diabetic macrovascular and microvascular disease. In patients with diabetes, we hypothesised that protein glycosylation can alter nitric oxide binding affinity of haemoglobin and plasma proteins, hence reducing nitric oxide availability and causing an alteration in nitric oxide metabolism.

Item Type: Article
Uncontrolled Keywords: adult,age of onset,biological availability,blood glucose,blood specimen collection,cholesterol,diabetes mellitus, type 1,electron spin resonance spectroscopy,glycosylation,hemoglobin a, glycosylated,hemoglobins,humans,kinetics,nitrates,nitric oxide,nitrites,triglycerides
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 09 Mar 2015 07:29
Last Modified: 21 Apr 2020 23:54
URI: https://ueaeprints.uea.ac.uk/id/eprint/52421
DOI: 10.1007/s00125-002-0956-9

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