Abnormal metabolic fate of nitric oxide in Type I diabetes mellitus

Milsom, A B, Jones, C J H, Goodfellow, J, Frenneaux, M P, Peters, J R and James, P E (2002) Abnormal metabolic fate of nitric oxide in Type I diabetes mellitus. Diabetologia, 45 (11). pp. 1515-22. ISSN 0012-186X

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Reduced bioavailability of endothelium-derived nitric oxide is implicated in diabetic macrovascular and microvascular disease. In patients with diabetes, we hypothesised that protein glycosylation can alter nitric oxide binding affinity of haemoglobin and plasma proteins, hence reducing nitric oxide availability and causing an alteration in nitric oxide metabolism.

Item Type: Article
Uncontrolled Keywords: adult,age of onset,biological availability,blood glucose,blood specimen collection,cholesterol,diabetes mellitus, type 1,electron spin resonance spectroscopy,glycosylation,hemoglobin a, glycosylated,hemoglobins,humans,kinetics,nitrates,nitric oxide,nitrites,triglycerides,sdg 3 - good health and well-being ,/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User: Pure Connector
Date Deposited: 09 Mar 2015 07:29
Last Modified: 22 Apr 2023 22:31
URI: https://ueaeprints.uea.ac.uk/id/eprint/52421
DOI: 10.1007/s00125-002-0956-9

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