Impaired energetics in heart failure - a new therapeutic target

Ormerod, Julian O M, Ashrafian, Houman and Frenneaux, Michael P (2008) Impaired energetics in heart failure - a new therapeutic target. Pharmacology & Therapeutics, 119 (3). pp. 264-74. ISSN 0163-7258

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Heart failure is a syndrome of huge and growing importance worldwide. It is widely accepted that the energy status of the myocardium in heart failure is impaired, irrespective of etiology. Agents which modify cardiac substrate utilisation have the potential to ameliorate this energy deficiency by increasing cardiac mechanical efficiency. This may represent a new therapeutic paradigm in heart failure. In this review we discuss existing and new agents that alter cardiac substrate use and summarise the data on clinical efficacy.

Item Type: Article
Uncontrolled Keywords: animals,carbohydrate metabolism,energy metabolism,heart failure,humans,models, biological,myocardium,oxidation-reduction
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 09 Mar 2015 07:28
Last Modified: 21 Oct 2022 00:36
DOI: 10.1016/j.pharmthera.2008.05.007

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