Exercise capacity in hypertrophic cardiomyopathy. Role of stroke volume limitation, heart rate, and diastolic filling characteristics

Lele, Suhas S., Thomson, Helen L., Seo, Hiromi, Belenkie, Israel, McKenna, William J. and Frenneaux, Michael P. (1995) Exercise capacity in hypertrophic cardiomyopathy. Role of stroke volume limitation, heart rate, and diastolic filling characteristics. Circulation, 92 (10). pp. 2886-94. ISSN 0009-7322

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Abstract

We previously showed that exercise capacity in patients with hypertrophic cardiomyopathy (HCM) is related to peak exercise cardiac output. Cardiac output augmentation during exercise is normally dependent on heart rate (HR) response and stroke volume (SV) augmentation by increased left ventricular end-diastolic volume and/or increased contractility. We hypothesized that in contrast to normal subjects, peak exercise capacity in patients with HCM is determined by the diastolic filling characteristics of the left ventricle during exercise, which would in turn determine the degree to which SV is augmented, and that HR is a relatively unimportant determinant of peak exercise capacity.

Item Type:	Article
Uncontrolled Keywords:	adult,cardiomyopathy, hypertrophic,case-control studies,exercise test,exercise tolerance,female,gated blood-pool imaging,heart,hemodynamics,humans,male,oxygen consumption,sodium pertechnetate tc 99m,stroke volume,ventricular function, left
Faculty \ School:	Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups:	Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User:	Pure Connector
Date Deposited:	27 Feb 2015 13:20
Last Modified:	23 Apr 2023 00:58
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52377
DOI:	10.1161/01.CIR.92.10.2886

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