Enalapril for severe heart-failure in infancy

Frenneaux, M., Stewart, R. A ., Newman, C. M. and Hallidie-Smith, K. A. (1989) Enalapril for severe heart-failure in infancy. Archives of Disease in Childhood, 64 (2). pp. 219-223. ISSN 0003-9888

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Eight infants aged between 4 days and 12 weeks with severe heart failure that was refractory to optimal conventional treatment with diuretics were treated with enalapril. The starting dose was 0.1 mg/kg/day, increasing according to response to 0.12-0.43 mg/kg/day. One infant with severe myocarditis did not tolerate enalapril because of hypotension and later died of intractable heart failure. Six of the remaining patients had congenital systemic to pulmonary shunts and one had a simple aortic coarctation. Two weeks after starting enalapril the clinical features of heart failure had improved in all the infants, the mean (SEM) plasma sodium concentration had increased from 129 (2.4) to 136 (1.1) mmol/l and plasma urea concentration had fallen from 7.0 (0.85) to 2.9 (0.85) mmol/l. These data suggest that enalapril is a potentially useful treatment for severe heart failure in infancy.

Item Type: Article
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
UEA Research Groups: Faculty of Medicine and Health Sciences > Research Groups > Cardiovascular and Metabolic Health
Depositing User: Pure Connector
Date Deposited: 25 Feb 2015 06:15
Last Modified: 04 Mar 2024 17:24
URI: https://ueaeprints.uea.ac.uk/id/eprint/52336
DOI: 10.1136/adc.64.2.219

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