Multicentre double-blind randomized controlled trial of perhexiline as a metabolic modulator to augment myocardial protection in patients with left ventricular hypertrophy undergoing cardiac surgery

Senanayake, Eshan L, Howell, Neil J, Ranasinghe, Aaron M, Drury, Nigel E, Freemantle, Nick, Frenneaux, Michael, Oelofse, Tessa, Green, David, Wilson, Ian C, Rooney, Stephen J, Mascaro, Jorge, Graham, Timothy R, Bhudia, Sunil, Lewis, Michael and Pagano, Domenico (2015) Multicentre double-blind randomized controlled trial of perhexiline as a metabolic modulator to augment myocardial protection in patients with left ventricular hypertrophy undergoing cardiac surgery. European Journal of Cardio-Thoracic Surgery, 48 (3). pp. 354-362. ISSN 1873-734X

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Abstract

Patients undergoing cardiac surgery require adequate myocardial protection. Manipulating myocardial metabolism may improve the extent of myocardial protection. Perhexiline has been shown to be an effective anti-anginal agent due to its metabolic modulation properties by inhibiting the uptake of free fatty acids into the mitochondrion, and thereby promoting a more efficient carbohydrate-driven myocardial metabolism. Metabolic modulation may augment myocardial protection, particularly in patients with left ventricular hypertrophy (LVH) known to have a deranged metabolic state and are at risk of poor postoperative outcomes. This study aimed to evaluate the role of perhexiline as an adjunct in myocardial protection in patients with LVH secondary to aortic stenosis (AS), undergoing an aortic valve replacement (AVR).

Item Type: Article
Additional Information: © The Author 2014. Published by Oxford University Press on behalf of the European Association for Cardio-Thoracic Surgery. All rights reserved.
Uncontrolled Keywords: myocardial protection,left ventricular hypertrophy,perhexiline,metabolic modulation,aortic stenosis,cardiac surgery
Faculty \ School: Faculty of Medicine and Health Sciences > Norwich Medical School
Depositing User: Pure Connector
Date Deposited: 25 Feb 2015 06:14
Last Modified: 21 Apr 2020 23:52
URI: https://ueaeprints.uea.ac.uk/id/eprint/52286
DOI: 10.1093/ejcts/ezu452

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