Autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation: Analysis of 533 adult patients who underwent transplantation at King’s College Hospital

Wang, Meng, Wang, Wenjia, Abeywardane, Ayesha and Mijovic, Aleksandar (2015) Autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation: Analysis of 533 adult patients who underwent transplantation at King’s College Hospital. Biology of Blood and Marrow Transplantation, 21 (1). pp. 60-66. ISSN 1523-6536

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Abstract

Autoimmune hemolytic anemia (AIHA) is a recognized complication of hematopoietic stem cell transplantation (HSCT); it is often refractory to treatment and carries a high mortality. To improve understanding of the incidence, risk factors, and clinical outcome of post-transplantation AIHA, we analyzed 533 patients who received allogeneic HSCT, and we identified 19 cases of AIHA after HSCT (overall incidence, 3.6%). The median time to onset, from HSCT to AIHA, was 202 days. AIHA was associated with HSCT from unrelated donors (hazard ratio [HR], 5.28; 95% confidence interval [CI], 1.22 to 22.9; P ¼ .026). In the majority (14 of 19; 74%) of AIHA patients, multiple agents for treatment were required, with only 9 of 19 (47%) patients achieving complete resolution of AIHA. Patients with post-transplantation AIHA had a higher overall mortality (HR, 2.48; 95% CI, 1.33 to 4.63; P ¼ .004), with 36% (4 of 11 cases) of deaths attributable to AIHA.

Item Type: Article
Faculty \ School: Faculty of Science > School of Computing Sciences
Related URLs:
Depositing User: Pure Connector
Date Deposited: 10 Feb 2015 13:22
Last Modified: 21 Apr 2020 23:51
URI: https://ueaeprints.uea.ac.uk/id/eprint/52219
DOI: 10.1016/j.bbmt.2014.09.009

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