Wang, Meng, Wang, Wenjia, Abeywardane, Ayesha and Mijovic, Aleksandar (2015) Autoimmune hemolytic anemia after allogeneic hematopoietic stem cell transplantation: Analysis of 533 adult patients who underwent transplantation at King’s College Hospital. Biology of Blood and Marrow Transplantation, 21 (1). pp. 60-66. ISSN 1523-6536

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Abstract

Autoimmune hemolytic anemia (AIHA) is a recognized complication of hematopoietic stem cell transplantation (HSCT); it is often refractory to treatment and carries a high mortality. To improve understanding of the incidence, risk factors, and clinical outcome of post-transplantation AIHA, we analyzed 533 patients who received allogeneic HSCT, and we identified 19 cases of AIHA after HSCT (overall incidence, 3.6%). The median time to onset, from HSCT to AIHA, was 202 days. AIHA was associated with HSCT from unrelated donors (hazard ratio [HR], 5.28; 95% confidence interval [CI], 1.22 to 22.9; P ¼ .026). In the majority (14 of 19; 74%) of AIHA patients, multiple agents for treatment were required, with only 9 of 19 (47%) patients achieving complete resolution of AIHA. Patients with post-transplantation AIHA had a higher overall mortality (HR, 2.48; 95% CI, 1.33 to 4.63; P ¼ .004), with 36% (4 of 11 cases) of deaths attributable to AIHA.

Item Type:	Article
Faculty \ School:	Faculty of Science > School of Computing Sciences
Related URLs:	http://www.bbmt.org/article/S1083-8791(1...
Depositing User:	Pure Connector
Date Deposited:	10 Feb 2015 13:22
Last Modified:	21 Apr 2020 23:51
URI:	https://ueaeprints.uea.ac.uk/id/eprint/52219
DOI:	10.1016/j.bbmt.2014.09.009

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